Cutting edge: IgE plays an active role in tumor immunosurveillance in mice

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dc.contributor.authorNigro, Elisa A.
dc.contributor.authorBrini, Anna T.
dc.contributor.authorYenagi, Vijay A.
dc.contributor.authorFerreira, Lorena M.
dc.contributor.authorAchatz-Straussberger, Gertrude
dc.contributor.authorAmbrosi, Alessandro
dc.contributor.authorSanvito, Francesca
dc.contributor.authorSoprana, Elisa
dc.contributor.authorVan Anken, Eelco
dc.contributor.authorAchatz, Gernot
dc.contributor.authorSiccardi, Antonio G.
dc.contributor.authorVangelista, Luca
dc.date.accessioned2017-01-12T06:26:47Z
dc.date.available2017-01-12T06:26:47Z
dc.date.issued2016-10-01
dc.description.abstractExogenous IgE acts as an adjuvant in tumor vaccination in mice, and therefore a direct role of endogenous IgE in tumor immunosurveillance was investigated. By using genetically engineered mice, we found that IgE ablation rendered mice more susceptible to the growth of transplantable tumors. Conversely, a strengthened IgE response provided mice with partial or complete resistance to tumor growth, depending on the tumor type. By genetic crosses, we showed that IgE-mediated tumor protection was mostly lost in mice lacking FceRI. Tumor protection was also lost after depletion of CD8+ T cells, highlighting a cross-Talk between IgE and T cell- mediated tumor immunosurveillance. Our findings provide the rationale for clinical observations that relate atopy with a lower risk for developing cancer and open new avenues for the design of immunotherapeutics relevant for clinical oncology. The Journal of Immunology, 2016, 197: 2583-2588.ru_RU
dc.identifier.citationNigro, E. A., Brini, A. T., Yenagi, V. A., Ferreira, L. M., Achatz-Straussberger, G., Ambrosi, A., ... Vangelista, L. (2016). Cutting edge: IgE plays an active role in tumor immunosurveillance in mice. Journal of Immunology, 197(7), 2583-2588. DOI: 10.4049/jimmunol.1601026ru_RU
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2244
dc.language.isoenru_RU
dc.publisherJournal of Immunologyru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectneoplasmsru_RU
dc.subjectimmunoglobulin Eru_RU
dc.subjectimmunologic monitoringru_RU
dc.titleCutting edge: IgE plays an active role in tumor immunosurveillance in miceru_RU
dc.typeArticleru_RU

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