Cutting edge: IgE plays an active role in tumor immunosurveillance in mice
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Date
2016-10-01
Authors
Nigro, Elisa A.
Brini, Anna T.
Yenagi, Vijay A.
Ferreira, Lorena M.
Achatz-Straussberger, Gertrude
Ambrosi, Alessandro
Sanvito, Francesca
Soprana, Elisa
Van Anken, Eelco
Achatz, Gernot
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Immunology
Abstract
Exogenous IgE acts as an adjuvant in tumor vaccination in mice, and therefore a direct role of endogenous IgE in tumor immunosurveillance was investigated. By using genetically engineered mice, we found that IgE ablation rendered mice more susceptible to the growth of transplantable tumors. Conversely, a strengthened IgE response provided mice with partial or complete resistance to tumor growth, depending on the tumor type. By genetic crosses, we showed that IgE-mediated tumor protection was mostly lost in mice lacking FceRI. Tumor protection was also lost after depletion of CD8+ T cells, highlighting a cross-Talk between IgE and T cell- mediated tumor immunosurveillance. Our findings provide the rationale for clinical observations that relate atopy with a lower risk for developing cancer and open new avenues for the design of immunotherapeutics relevant for clinical oncology. The Journal of Immunology, 2016, 197: 2583-2588.
Description
Keywords
neoplasms, immunoglobulin E, immunologic monitoring
Citation
Nigro, E. A., Brini, A. T., Yenagi, V. A., Ferreira, L. M., Achatz-Straussberger, G., Ambrosi, A., ... Vangelista, L. (2016). Cutting edge: IgE plays an active role in tumor immunosurveillance in mice. Journal of Immunology, 197(7), 2583-2588. DOI: 10.4049/jimmunol.1601026