Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model
| dc.contributor.author | Golriz, Mohammad | |
| dc.contributor.author | Fonouni, Hamidreza | |
| dc.contributor.author | Kuttymuratov, Gani | |
| dc.contributor.author | Esmaeilzadeh, Majid | |
| dc.contributor.author | Jarahian, Parvin | |
| dc.contributor.author | Longerich, Thomas | |
| dc.contributor.author | Tahmasbi, Morva | |
| dc.contributor.author | Faridar, Alireza | |
| dc.contributor.author | Abbasi, Sepehr | |
| dc.contributor.author | Mehrabi, Arianeb | |
| dc.contributor.author | Gebhard, Marta M. | |
| dc.date.accessioned | 2018-06-06T10:56:36Z | |
| dc.date.available | 2018-06-06T10:56:36Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Currently, due to lack of optimal donors, more marginal organs are transplanted. Therefore, there is a high interest to ameliorate preischemic organ preservation, especially for critical donor organs. In this regard, a new histidinetryptophane ketoglutarate (HTK-N) solution has been designed and its protective efficacy was compared with the standard preservation solutionsdUniversity of Wisconsin solution and standard HTK or Custodiol (Bretschneider’s solution). Methods: Seventy-two landrace pigs were included into the study, as donors and recipients. The donor kidneys were perfused during explantation with cold University of Wisconsin solution (n Z 12), standard HTK (n Z 12), or HTK-N solutions (n Z 12), kept in the respective preservation solution at 4 C for 30 hours, implanted in the recipient pigs, and reperfused. The pigs survived in daily control for 7 days. The serum creatinine and blood urea nitrogen were assessed in pre- and postreperfusion phase on the 3rd day and 7th day posttransplantation. Additionally, tissue samples were taken to analyze the histopathological degree of tubular injury and regeneration before and after reperfusion. | en_US |
| dc.identifier.citation | Golriz, Mohammad, Fonouni, Hamidreza, Kuttymuratov, Gani, Esmaeilzadeh, Majid, Jarahian, Parvin, Longerich, Thomas, Tahmasbi, Morva, Faridar, Alireza, Abbasi, Sepehr, Mehrabi, Arianeb, Gebhard, Marta M. (2015) Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model. Asian Journal of Surgery | en_US |
| dc.identifier.other | 10.1016/j.asjsur.2015.07.001 | |
| dc.identifier.uri | http://nur.nu.edu.kz/handle/123456789/3320 | |
| dc.language.iso | en | en_US |
| dc.publisher | Asian Journal of Surgery | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject | ischemia reperfusion injury | en_US |
| dc.subject | kidney transplantation | en_US |
| dc.subject | preservation solution | en_US |
| dc.title | Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model | en_US |
| dc.type | Article | en_US |
| workflow.import.source | science |