Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model
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Date
2015
Authors
Golriz, Mohammad
Fonouni, Hamidreza
Kuttymuratov, Gani
Esmaeilzadeh, Majid
Jarahian, Parvin
Longerich, Thomas
Tahmasbi, Morva
Faridar, Alireza
Abbasi, Sepehr
Mehrabi, Arianeb
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Publisher
Asian Journal of Surgery
Abstract
Currently, due to lack of optimal donors, more marginal organs are transplanted. Therefore, there is a high interest to ameliorate preischemic organ preservation, especially for critical donor organs. In this regard, a new histidinetryptophane
ketoglutarate (HTK-N) solution has been designed and its protective efficacy was compared with the standard preservation solutionsdUniversity of Wisconsin solution
and standard HTK or Custodiol (Bretschneider’s solution). Methods: Seventy-two landrace pigs were included into the study, as donors and recipients. The donor kidneys were perfused during explantation with cold University of Wisconsin solution (n Z 12), standard HTK (n Z 12), or HTK-N solutions (n Z 12), kept in the respective preservation solution at 4 C for 30 hours, implanted in the recipient pigs, and reperfused. The pigs survived in daily control for 7 days. The serum creatinine and blood urea nitrogen were assessed
in pre- and postreperfusion phase on the 3rd day and 7th day posttransplantation. Additionally, tissue samples were taken to analyze the histopathological degree of tubular injury and regeneration before and after reperfusion.
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Keywords
ischemia reperfusion injury, kidney transplantation, preservation solution
Citation
Golriz, Mohammad, Fonouni, Hamidreza, Kuttymuratov, Gani, Esmaeilzadeh, Majid, Jarahian, Parvin, Longerich, Thomas, Tahmasbi, Morva, Faridar, Alireza, Abbasi, Sepehr, Mehrabi, Arianeb, Gebhard, Marta M. (2015) Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model. Asian Journal of Surgery