Laboratory of Epidemiology and Public Health
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Item Metadata only PMS17 Cost-Effectiveness of denosumab vs. Brand or generic zoledronic acid in patients with prostate cancer in kazakhstan(2014-11-01) Bektur, C.; Nurgozhin, T.; C., BekturA phase III clinical trial demonstrated the advantage of denosumab over zoledronic acid(ZA) in delaying the first on-study and subsequent skeletal-related events(SREs) in patients with prostate cancer(PC). Recently, generic ZA became available. The purpose of this study was to examine the cost-effectiveness of denosumab vs. brand or generic ZA in the prevention of SREs in Kazakhstani patients with PC.Item Metadata only Endometrial histology in severely obese bariatric surgery candidates: an exploratory analysis(2015-05-01) Kaiyrlykyzy, Aiym; Freese, Kyle E.; Elishaev, Esther; Bovbjerg, Dana H.; Ramanathan, Ramesh; Hamad, Giselle G.; McCloskey, Carol; Althouse, Andrew D.; Huang, Marilyn; Edwards, Robert P.; Linkov, Faina; Aiym, KaiyrlykyzyAbstract BackgroundEndometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study was designed to explore the frequency and risk factors associated with endometrial pathology in cancer-free, severely obese, bariatric surgery candidates using the Pipelle endometrial sampling technique (SureFlex Preferred Curette, Bioteque America, Inc, New Taipei City, Taiwan). MethodsTwenty-nine severely obese bariatric surgery candidates with intact uteruses and no history of endometrial cancer or endometrial ablation were included in this subanalysis from a larger cohort of 47. Endometrial samples were obtained using a Pipelle endometrial suction curette at a single time point before surgery. Logistic regression was used to assess the relationship between body mass index and endometrial pathology when adjusting for age and race. ResultsOf the 29 successful biopsies, 8 (27.6%) were classified as abnormal endometrium: 1 was classified as complex atypical hyperplasia, 1 was classified as hyperplasia without atypia, 4 samples were identified with endometrial polyps, and 2 samples were identified with metaplasia. None presented with cancer. Increasing body mass index was significantly associated with higher risk of abnormal endometrium (OR = 1.19, 95% CI [1.03–1.36], P = .01). ConclusionsThe findings in this sample suggest that obesity may be associated with increased risk of having undiagnosed endometrial pathology. More thorough examination of relationships between levels of obesity and endometrial pathology are needed to better characterize high cancer risk groups who may benefit from introducing new screening measures.Item Metadata only Endometrial histology in severely obese bariatric surgery candidates: an exploratory analysis(2015-05-01) Kaiyrlykyzy, Aiym; Freese, Kyle E.; Elishaev, Esther; Bovbjerg, Dana H.; Ramanathan, Ramesh; Hamad, Giselle G.; McCloskey, Carol; Althouse, Andrew D.; Huang, Marilyn; Edwards, Robert P.; Linkov, Faina; Aiym, KaiyrlykyzyAbstract BackgroundEndometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study was designed to explore the frequency and risk factors associated with endometrial pathology in cancer-free, severely obese, bariatric surgery candidates using the Pipelle endometrial sampling technique (SureFlex Preferred Curette, Bioteque America, Inc, New Taipei City, Taiwan). MethodsTwenty-nine severely obese bariatric surgery candidates with intact uteruses and no history of endometrial cancer or endometrial ablation were included in this subanalysis from a larger cohort of 47. Endometrial samples were obtained using a Pipelle endometrial suction curette at a single time point before surgery. Logistic regression was used to assess the relationship between body mass index and endometrial pathology when adjusting for age and race. ResultsOf the 29 successful biopsies, 8 (27.6%) were classified as abnormal endometrium: 1 was classified as complex atypical hyperplasia, 1 was classified as hyperplasia without atypia, 4 samples were identified with endometrial polyps, and 2 samples were identified with metaplasia. None presented with cancer. Increasing body mass index was significantly associated with higher risk of abnormal endometrium (OR = 1.19, 95% CI [1.03–1.36], P = .01). ConclusionsThe findings in this sample suggest that obesity may be associated with increased risk of having undiagnosed endometrial pathology. More thorough examination of relationships between levels of obesity and endometrial pathology are needed to better characterize high cancer risk groups who may benefit from introducing new screening measures.Item Metadata only PIH18 Cost-Effectiveness Of 13-Valent Pneumococcal Conjugate Vaccination In Kazakhstan(Value in Health, 2015-05-01) Bektur, C; Nurgozhin, T; C, BekturThe aim of the study was to investigate the cost-effectiveness of 13-valent pneumococcal conjugate vaccine (PCV-13) programme for children in Kazakhstan from the perspective of Ministry of Health.Item Metadata only Pharmacokinetics of Ceftriaxone Included In Cellular Transport System(2015-08-01) Nurgozhin, T.; Gulyayev, A.; Lokhvytsky, S.; Yermekbayeva, B.; Sergazy, S.; Shulgau, Z.; Berikkhanova, K.; T., NurgozhinItem Metadata only Evaluation of health outcomes and cost-effectiveness of 13-valent Pneumococcal Conjugate Vaccination for infants in Kazakhstan(2015-08-01) Bektur, C.R.; Nurgozhin, T.S.; C.R., BekturItem Metadata only PHP167 Influence of Some Factors on The Morphological Structure of Spermatozoa In Straight Intestine During Forensic - Medical Examination of Sodomy(2015-11-01) Zhakupova, T; Turgambayeva, A; Mussina, A; Bukeyeva, Z; Kossumov, A; T, ZhakupovaItem Open Access Diabetes prevalence, awareness and treatment and their correlates in older persons in urban and rural population in the Astana region, Kazakhstan(2016-02-01) Supiyev, Adil; Kossumov, Alibek; Kassenova, Aliya; Nurgozhin, Talgat; Zhumadilov, Zhaxybay; Peasey, Anne; Bobak, Martin; Adil, SupiyevAbstract AimsThe evidence on the prevalence and distribution of diabetes and its determinants in Central Asia is sparse. The aim of the present study was to investigate the prevalence, awareness, treatment, and control of diabetes and factors associated with these characteristics in the population of Astana (capital) city and adjacent rural area in Kazakhstan. MethodsParticipants aged 50-75 years old, residing in Astana city (the capital) and Akmol village were invited to participate in a cross-sectional study. The subjects were randomly selected from polyclinic registers. A total of 953 adults were interviewed (response rate 59%), and their fasting plasma glucose, blood pressure, height and weight were measured. Diabetes was defined as fasting plasma glucose (FPG) ≥7.0mmol/l (126mg/dl) and/or being on diabetes medication. ResultsThe overall prevalence of diabetes was 12.5%, and it was almost twice higher in the urban residents (16.3%) than in the rural population (8.6%). Diabetes prevalence was associated with age, men sex, hypertension, obesity, and Russian ethnicity. Among subjects with diabetes, 72.3% were aware of their condition; 65.6% were on treatment and 27.7% had controlled fasting plasma glucose. The awareness, treatment and control of diabetes were substantially higher in the urban population and among women. ConclusionsThe large differences in all diabetes indices between urban and rural regions, if confirmed in larger studies, may suggest an impact of westernised and urbanised lifestyle as well as access to health care.Item Metadata only PIN23 Economic Evaluation of Protease Inhibitors for the Treatment of Patients with Genotype 1 Chronic Hepatitis C in Kazakhstan(2016-11-01) Almadiyeva, A.; Ibrayev, S.; Turgambayeva, A.; Nurgozhin, T.; A., AlmadiyevaItem Open Access Genetic analysis of hemagglutinin proteins of H3 and H1 subtypes in Kazakhstan(Genetika-Belgrade, 2019) Gritsenko, Dilyara; Pozharsky, Aleksandr; Deryabina, Nina; Kassenova, Aliya; Galiakparov, NurbolThe influenza is one of the most dangerous and widespread infectious diseases on the planet. A natural reservoir of the influenza A virus is wild waterfowl, which subsequently contribute to the spread of viral infection among domestic animals. Currently, different influenza A subtypes were isolated from various animal species and their genetic diversity were investigated with the subsequent possibility to predict the places of outbreaks and the transfer between species. An investigation of genetic diversity of influenza A virus is also important for a timely response by developing suitable vaccines to the emergence of new strains. In the work, we investigated two subtypes of hemagglutinin (H3, H1) from wild waterfowl in the Republic of Kazakhstan (RK). This work was aimed to determine the homology between these subtypes and currently known isolates from the NCBI database. H3N8 isolates from Kazakhstan were located in a monophyletic group together with isolates from Mongolia and Altai according to phylogenetic analysis of the hemagglutinin sequences . The hemagglutinin homology of H3N8 isolates from Kazakhstan and A/eq/Richmond/1/2007 vaccine strain was 86.07% and with A/eq/Ohio/2003 vaccine strain was 86, 24%. In the case of H1N1 isolates from Kazakhstan, the highest hemagglutinin homology was with isolates from Europe. The homology with the A/California/07/2009 (H1N1) vaccine strain was 81.27%. Important amino acids of cleavage and receptor binding sites were not variable in both H3 and H1 subtypes. The investigation of antigenic sites showed presence of variations in all five sites for H3 subtype and in 4 sites for H1.Item Open Access The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults(Elsevier, 2019-07-18) Zhumadilov, Zhaxybay; Supiyev, Adil; Geldsetzer, Pascal; Manne-Goehler, Jennifer; Marcus, Maja-Emilia; Ebert, Cara; Wesseh, Chea S; Tsabedze, Lindiwe; Sturua, Lela; Bahendeka, Silver K; Sibai, Abla M; Quesnel-Crooks, Sarah; Norov, Bolormaa; Mwangi, Kibachio J; Mwalim, Omar; Wong-McClure, Roy; Mayige, Mary T; Martins, Joao S; Lunet, Nuno; Labadarios, Demetre; Karki, Khem B; Kagaruki, Gibson B; Jorgensen, Jutta M A; Hwalla, Nahla C; Houinato, Dismand; Houehanou, Corine; Msaidié, Mohamed; Guwatudde, David; Gurung, Mongal S; Gathecha, Gladwell; Dorobantu, Maria; Damasceno, Albertino; Bovet, Pascal; Bicaba, Brice W; Aryal, Krishna K; Andall-Brereton, Glennis; Andall-Brereton, Glennis; Agoudavi, Kokou; Stokes, Andrew; Davies, Justine I; Bärnighausen, Till; Atun, Rifat; Vollmer, Sebastian; Jaacks, Lindsay MOur study provides important evidence for the design and targeting of health policies and service interventions for hypertension in LMICs. We show at what steps and for whom there are gaps in the hypertension care process in each of the 44 countries in our study. We also identified countries in each world region that perform better than expected from their economic development, which can direct policy makers to important policy lessons. Given the high disease burden caused by hypertension in LMICs, nationally representative hypertension care cascades, as constructed in this study, are an important measure of progress towards achieving universal health coverage.