Research Institute of Experimental and Clinical Pharmacology and Pharmacy
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Item Metadata only PCN99 Cost-Effectiveness Evaluation of Sunitinib as First-Line Targeted Therapy for Metastatic Renal Cell Carcinoma in Kazakhstan(2014-05-01) Kostyuk, A.; Nurgozhin, T.; Mazhitov, T.; Almadiyeva, A.; A., KostyukItem Metadata only Item Metadata only Cytisin Amidophosphate – Promising Role for The Liver Treatment(2015-08-01) Gulyayev, A.; Shulgau, Z.; Yermekbayeva, B.; Sergazy, S.; Nurgozhin, T.; A., GulyayevItem Metadata only Cardioprotective properties of polyphenol concentrate in Rat model of Doxorubicin-induced Cardiomyopathy(2015-08-01) Shulgau, Z.; Gulyayev, A.; Yermekbayeva, B.; Adilgozhina, G.; Tritek, V.; Nurgozhin, T.; Z., ShulgauPresent study aimed to investigate possible cardioprotective properties of polyphenol concentrates obtained from Cabernet Sauvignon type of Kazakhstani grapes using rat model doxorubicin-induced cardiomyopathy.Item Open Access Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy(Oncotarget, 2016-03-07) Mao, Xiao-Yuan; Tokay, Tursonjan; Zhou, Hong-Hao; Jin, Wei-LinEpileptic seizures are frequently caused by brain tumors. Traditional anti-epileptic treatments do not acquire satisfactory responses. Preoperative and postoperative seizures seriously influence the quality of life of patients. Thus, tumor-associated epilepsy (TAE) is an important subject of the current research. The delineation of the etiology of epileptogenesis in patients with primary brain tumor may help to find the novel and effective drug targets for treating this disease. In this review, we describe the current status of treatment of TAE. More importantly, we focus on the factors that are involved in the functional connectivity between tumors and stromal cells. We propose that there exist two modes, namely, long-range and short-range modes, which likely trigger neuronal hyperexcitation and subsequent epileptic seizures. The long-range mode is referred to as factors released by tumors including glutamate and GABA, binding to the corresponding receptor on the cellular membrane and causing neuronal hyperactivity, while the short-range mode is considered to involve direct intracellular communication between tumor cells and stromas. Gap junctions and tunneling nanotube network are involved in cellular interconnections. Future investigations focused on those two modes may find a potential novel therapeutic target for treating TAE.