Reports

Permanent URI for this collection

https://testres.nu.edu.kz/handle/123456789/4169

Browse

Browsing Reports by Issue Date

Filter results by year or month
Now showing 1 - 1 of 1
  • Thumbnail Image
    ItemRestricted
    Electrochemical synthesis of spirocyclic morpholines and tetrahydrofurans via an oxidative dearomatisation strategy
    (2024-04-13) Kaipov, Almaz; Hayrapetyan, Davit
    In search for developing synthetic routes towards spirocyclic morpholines and tetrahydrofurans, we developed a convenient electrochemical protocol for dearomatization of methoxy-benzene derivatives. The electrochemical oxidation of the electron-rich benzene ring followed by intramolecular capture of the cation-radical intermediates accessed desired spirocyclic products. The scope of the reaction demonstrated tolerance of various functional groups such as alkenes, alcohols, bromines, fluorines, trifuoromethyl, cyano, ester and amides with reaction yield varying between 46-91%.