Center for Life Sciences

Permanent URI for this community

https://testres.nu.edu.kz/handle/123456789/107

Browse

Browsing Center for Life Sciences by Author "Agdzhoyan, Anastasiya"

Now showing 1 - 2 of 2
  • Thumbnail Image
    ItemOpen Access
    Deep phylogenetic analysis of haplogroup G1 provides estimates of SNP and STR utation rates on the human Y-Chromosome and reveals migrations of Iranic speakers
    (PLOS ONE, 2015-04-07) Balanovsky, Oleg; Zhabagin, Maxat; Agdzhoyan, Anastasiya; Chukhryaeva, Marina; Zaporozhchenko, Valery; Utevska, Olga; Highnam, Gareth; Sabitov, Zhaxylyk; Greenspan, Elliott; Dibirova, Khadizhat; Skhalyakho, Roza; Kuznetsova, Marina; Koshel, Sergey; Yusupov, Yuldash; Nymadawa, Pagbajabyn; Zhumadilov, Zhaxybay; Pocheshkhova, Elvira; Haber, Marc; Zalloua, Pierre A.; Yepiskoposyan, Levon; Dybo, Anna; Tyler-Smith, Chris; Balanovska, Elena
    Y-chromosomal haplogroup G1 is a minor component of the overall gene pool of South- West and Central Asia but reaches up to 80% frequency in some populations scattered within this area. We have genotyped the G1-defining marker M285 in 27 Eurasian populations (n= 5,346), analyzed 367 M285-positive samples using 17 Y-STRs, and sequenced ~11 Mb of the Y-chromosome in 20 of these samples to an average coverage of 67X. This allowed detailed phylogenetic reconstruction. We identified five branches, all with high geographical specificity: G1-L1323 in Kazakhs, the closely related G1-GG1 in Mongols, G1- GG265 in Armenians and its distant brother clade G1-GG162 in Bashkirs, and G1-GG362 in West Indians.
  • No Thumbnail Available
    ItemOpen Access
    The genetic history of admixture across inner Eurasia
    (Nature Ecology & Evolution, 2019-04) Jeong, Choongwon; Balanovsky, Oleg; Lukianova, Elena; Kahbatkyzy, Nurzhibek; Flegontov, Pavel; Zaporozhchenko, Valery; Immell, Alexander; Wang, Chuan-Chao; Ixan, Olzhas; Khussainova, Elmira; Bekmanov, Bakhytzhan; Zaibert, Victor; Lavryashina, Maria; Pocheshkhova, Elvira; Yusupov, Yuldash; Agdzhoyan, Anastasiya; Koshel, Sergey; Bukin, Andrei; Nymadawa, Pagbajabyn; Turdikulova, Shahlo; Dalimova, Dilbar; Churnosov, Mikhail; Skhalyakho, Roza; Daragan, Denis; Bogunov, Yuri; Bogunova, Anna; Shtrunov, Alexandr; Dubova, Nadezhda; Zhabagin, Maxat; Yepiskoposyan, Levon; Churakov, Vladimir; Pislegin, Nikolay; Damba, Larissa; Saroyants, Ludmila; Dibirova, Khadizhat; Atramentova, Lubov; Utevska, Olga; Idrisov, Eldar; Kamenshchikova, Evgeniya; Evseeva, Irina; Metspalu, Mait; Outram, Alan K.; Robbeets, Martine; Djansugurova, Leyla; Balanovska, Elena; Schiffels, Stephan; Haak, Wolfgang; Reich, David; Krause, Johannes
    The indigenous populations of inner Eurasia-a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra-harbour tremendous diversity in their genes, cultures and languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine and Uzbekistan. We furthermore report additional damage-reduced genome-wide data of two previously published individuals from the Eneolithic Botai culture in Kazakhstan (~5,400 BP). We find that present-day inner Eurasian populations are structured into three distinct admixture clines stretching between various western and eastern Eurasian ancestries, mirroring geography. The Botai and more recent ancient genomes from Siberia show a decrease in contributions from so-called 'ancient North Eurasian' ancestry over time, which is detectable only in the northern-most 'forest-tundra' cline. The intermediate 'steppe-forest' cline descends from the Late Bronze Age steppe ancestries, while the 'southern steppe' cline further to the south shows a strong West/South Asian influence. Ancient genomes suggest a northward spread of the southern steppe cline in Central Asia during the first millennium BC. Finally, the genetic structure of Caucasus populations highlights a role of the Caucasus Mountains as a barrier to gene flow and suggests a post-Neolithic gene flow into North Caucasus populations from the steppe.