Deep phylogenetic analysis of haplogroup G1 provides estimates of SNP and STR utation rates on the human Y-Chromosome and reveals migrations of Iranic speakers
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Date
2015-04-07
Authors
Balanovsky, Oleg
Zhabagin, Maxat
Agdzhoyan, Anastasiya
Chukhryaeva, Marina
Zaporozhchenko, Valery
Utevska, Olga
Highnam, Gareth
Sabitov, Zhaxylyk
Greenspan, Elliott
Dibirova, Khadizhat
Journal Title
Journal ISSN
Volume Title
Publisher
PLOS ONE
Abstract
Y-chromosomal haplogroup G1 is a minor component of the overall gene pool of South-
West and Central Asia but reaches up to 80% frequency in some populations scattered
within this area. We have genotyped the G1-defining marker M285 in 27 Eurasian populations (n= 5,346), analyzed 367 M285-positive samples using 17 Y-STRs, and sequenced ~11 Mb of the Y-chromosome in 20 of these samples to an average coverage of 67X. This allowed detailed phylogenetic reconstruction. We identified five branches, all with high geographical specificity: G1-L1323 in Kazakhs, the closely related G1-GG1 in Mongols, G1- GG265 in Armenians and its distant brother clade G1-GG162 in Bashkirs, and G1-GG362 in West Indians.
Description
Keywords
Y-chromosomal haplogroup, haplogroup G1, SNP and STR Mutation Rates
Citation
Balanovsky O, Zhabagin M, Agdzhoyan A, Chukhryaeva M, Zaporozhchenko V, Utevska O, et al. (2015) Deep Phylogenetic Analysis of Haplogroup G1 Provides Estimates of SNP and STR Mutation Rates on the Human Y-Chromosome and Reveals Migrations of Iranic Speakers. PLoS ONE 10(4): e0122968. doi:10.1371/journal.pone.0122968