Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis
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Date
2013
Authors
Catanzaro, R.
Zerbinati, N.
Solimene, U.
Celep, G.
Marotta, F.
Kushugulova, A.
Milazzo, M.
Tomella, C.
Bertuccelli, G.
Zhumadilov, Z.
Journal Title
Journal ISSN
Volume Title
Publisher
Drug Discoveries & Therapeutics. DOI: 10.5582/ddt.2013.v7.5.196
Abstract
The aim of this study was to test for a potential anticarcinogenic effect of Celergen, a marine derivative devoid of traceable amounts of inorganic arsenic, on cell proliferation, cell cycle progression and apoptosis in the HepG2 human liver cancer cell
line. Celergen significantly inhibited the proliferation of cancer cells in a dose-dependent manner while limiting the cell cycle progression at the G1 phase and
significantly inducing apoptosis. Further examination showed that Celergen enhanced expression of the p21CIPl1WAF1, GADD153 genes and downregulated the
c-myc gene. These results suggest that Celergen exerts promising chemopreventive properties to be further investigated.
Description
Keywords
antimutagenic effect, cell cycle, apoptosis, celergen, marine compound, Research Subject Categories::MEDICINE
Citation
DOI: 10.5582/ddt.2013.v7.5.196