ASSOCIATION OF GENETIC POLYMORPHISMS WITH COMPLICATIONS OF IMPLANTED LVAD DEVICES IN PATIENTS WITH CONGESTIVE HEART FAILURE: A KAZAKHSTANI STUDY
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Date
2022-05-04
Authors
Zhalbinova, Madina R.
Rakhimova, Saule E.
Kozhamkulov, Ulan A.
Akilzhanova, Gulbanu A.
Kaussova, Galina K.
Akilzhanov, Kenes R.
Pya, Yuriy V.
Lee, Joseph H.
Bekbossynova, Makhabbat S.
Akilzhanova, Ainur R.
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Personalized Medicine
Abstract
The left ventricular assist device (LVAD) is one of the alternative treatments for heart failure
(HF) patients. However, LVAD support is followed by thrombosis, and bleeding complications which
are caused by high non-physiologic shear stress and antithrombotic/anticoagulant therapy. A high
risk of complications occurs in the presence of the genotype polymorphisms which are involved in the
coagulation system, hemostasis function and in the metabolism of the therapy. The aim of the study
was to investigate the influence of single-nucleotide polymorphisms (SNP) in HF patients with LVAD
complications. We analyzed 21 SNPs in HF patients (n = 98) with/without complications, and healthy
controls (n = 95). SNPs rs9934438; rs9923231 in VKORC1, rs5918 in ITGB3 and rs2070959 in UGT1A6
demonstrated significant association with HF patients’ complications (OR (95% CI): 3.96 (1.42–11.02),
p = 0.0057), (OR (95% CI): 3.55 (1.28–9.86), p = 0.011), (OR (95% CI): 5.37 (1.79–16.16), p = 0.0056)
and OR (95% CI): 4.40 (1.06–18.20), p = 0.044]. Genotype polymorphisms could help to predict
complications at pre- and post-LVAD implantation period, which will reduce mortality rate. Our
research showed that patients can receive treatment with warfarin and aspirin with a personalized
dosage and LVAD complications can be predicted by reference to their genotype polymorphisms in
VKORC1, ITGB3 and UGT1A6 genes.
Description
Keywords
Type of access: Open Access, genotype, polymorphism, heart failure, left ventricular assist device (LVAD), personalized medicine, thrombosis, bleeding
Citation
Zhalbinova, M. R., Rakhimova, S. E., Kozhamkulov, U. A., Akilzhanova, G. A., Kaussova, G. K., Akilzhanov, K. R., Pya, Y. V., Lee, J. H., Bekbossynova, M. S., & Akilzhanova, A. R. (2022). Association of Genetic Polymorphisms with Complications of Implanted LVAD Devices in Patients with Congestive Heart Failure: A Kazakhstani Study. Journal of Personalized Medicine, 12(5), 744. https://doi.org/10.3390/jpm12050744