SYNTHESIS OF 1,4-DIHYDROPIRIDINE DERIVATIVES IN MICROWAVE FLOW REACTOR
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Date
2022-08
Authors
Khrustaleva, Anastassiya
Khrustalev, Dmitriy
Yedrissov, Azamat
Mustafin, Marlen
Journal Title
Journal ISSN
Volume Title
Publisher
National Laboratory Astana
Abstract
1,4-Dihydropyridine derivatives (e.g. Nimodipine, Nifedipine, Nitrendipine), which belong to the group of calcium channel blockers, serve as effective drugs in the treatment of cardiovascular diseases. According to the World Health Organization (WHO), this disease class ranks first in terms of the number of deaths worldwide. Considering the unfavorable statistics of mortality from cardiovascular diseases, which is about 17 million people per year, the development of unique, cost- effective methods of obtaining 1,4-dihydropyridine derivatives is an urgent task.
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Keywords
Type of access: Embargo, 1,4-Dihydropyridine derivatives
Citation
Khrustaleva, A. Khrustalev, D. Yedrissov, A. Mustafin, M. (2022). Synthesis of 1,4-dihydropiridine derivatives in microwave flow reactor. National Laboratory Astana