Comparison of the sensitivity and specificity of urine cytology, urinary nuclear matrix protein-22 and multitarget fluorescence in situ hybridization assay in the detection of bladder cancer
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Date
2010
Authors
Kehinde, Elijah
Al-Mulla, Fahd
Kapila, Kusum
Anim, Jehoram T.
Journal Title
Journal ISSN
Volume Title
Publisher
Scandinavian Journal of Urology and Nephrology
Abstract
This study aimed to compare the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of urine cytology, BladderChek nuclear matrix protein-22 (NMP22) and UroVysion fluorescence in situ hybridization (FISH) tests in patients with newly diagnosed bladder cancer, those with recurrent bladder cancer, and those with bladder cancer but in remission during surveillance. Material and methods. Voided urine samples obtained from 178 patients with suspected or known bladder cancer about to undergo diagnostic or surveillance cystoscopy and 25 control
subjects without the disease were divided into four and used for urine culture and cytology, NMP22 BladderChek and UroVysion FISH tests.
Description
Keywords
Bladder cancer, diagnosis, NMP22, urine cytology, UroVysion FISH, Research Subject Categories::MEDICINE