PATIENTS RECEIVING HEMODIALYSIS DO NOT LOSE SARS-COV-2 ANTIBODIES MORE RAPIDLY THAN NON-RENAL CONTROLS: A PROSPECTIVE COHORT STUDY
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Date
2022
Authors
Parshina, Ekaterina
Zulkarnaev, Alexey
Tolkach, Alexey
Ivanov, Andrey
Kislyy, Pavel
Gaipov, Abduzhappar
Journal Title
Journal ISSN
Volume Title
Publisher
Renal Failure
Abstract
Background
Patients with end-stage kidney disease receiving maintenance hemodialysis (HD) are at increased risk for mortality after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared with the general population. However, it is currently unknown whether the long-term SARS-CoV-2 humoral and cellular immune responses in patients receiving HD are comparable to individuals with normal kidney function.
Method
The prospective cohort study included 24 patients treated with maintenance HD and 27 non-renal controls with confirmed history of coronavirus disease (COVID-19). In all participants the levels of specific IgG were quantified at three timepoints: 10, 18, and 26 weeks from disease onset. In a subgroup of patients, specific T-cell responses were evaluated.
Results
The seropositivity rate declined in controls over time and was 85% and 70.4% at weeks 18 and 26, respectively. All HD patients remained seropositive over the study period. Seropositivity rate at week 26 was greater among patients receiving HD: RR = 1.4 [95%CI: 1.17–1.94] (reciprocal of RR = 0.7 [95% CI: 0.52–0.86]), p = 0.0064. In both groups, IgG levels decreased from week 10 to week 26, but antibodies vanished more rapidly in controls than in HD group (ANOVA p = 0.0012). The magnitude of T-cell response was significantly lower in controls than in HD patients at weeks 10 (p = 0.019) and 26 (p = 0.0098) after COVID-19 diagnosis, but not at week 18.
Conclusion
Compared with non-renal adults, patients receiving HD maintain significant long-term humoral and cellular immune responses following natural COVID-19.
Description
Keywords
Type of access: Open Access, COVID-19, SARS-CoV-2, hemodialysis, antibody, cellular immunity
Citation
Parshina, E., Zulkarnaev, A., Tolkach, A., Ivanov, A. V., Kislyy, P., & Gaipov, A. (2022). Patients receiving hemodialysis do not lose SARS-CoV-2 antibodies more rapidly than non-renal controls: a prospective cohort study. Renal Failure, 44(1), 391–397. https://doi.org/10.1080/0886022x.2022.2042310