Assesing the cytokine content of human platelet-rich plasma
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Date
2016-05
Authors
Masoud, A.
Umbayev, B.
Olzhayev, F.
Idrissova, D.
Shramko, A.
Kaiyrlykyzy, A.
Askarova, Sh.
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Abstract
Human platelet-rich plasma (PRP) is plasma that is enriched with thrombocytes
at a concentration of 1000 * 109 per litre, higher than normal (150 - 350 * 109 per litre).
Thrombocytes are known to contain growth factors including IGF, PDGF, EGF, FGF, TGF-li,
PDEGF, VEGF or PDAF as well as thrombospondin and osteonectin. The release of these
growth factors is induced by thrombocyte activation resulting from their exposure to a variety of
substances such as thrombin, Calciom chloride or collagen. Growth factors are found in higher
concentrations in PRP than in blood, and could be used to facilitate wound healing at a faster
rate. Currently, PRP is employed in dentistry, dermatology, traumatology and orthopedics. In
developed countries, PRP is also actively used in treating acute and chronic skin lesions. Though
commercial devices for clinical preparation of autologous PRP are available, standardized
PRP-preparation protocols are yet to be developed. Furthermore, only a handful of research
work is aimed at optimizing methods of obtaining platelet-rich plasma. Therefore, two different
modifications of the Araki et al method, the most standardized of all available methods, were
used to prepare high cytokine-containing platelet-rich plasma.
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Keywords
Human platelet-rich plasma
Citation
Masoud A., Umbayev B., Olzhayev F., Idrissova D., Shramko A., Kaiyrlykyzy A., and Askarova Sh. 2016. Assesing the cytokine content of human platelet-rich plasma. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1504.