HONGHUA EXTRACT MEDIATED POTENT INHIBITION OF COVID‑19 HOST CELL PATHWAYS

dc.contributor.authorMadikyzy, Malika
dc.contributor.authorTilegen, Meruyert
dc.contributor.authorNazarbek, Guldan
dc.contributor.authorMu, Chenglin
dc.contributor.authorKutzhanova, Aidana
dc.contributor.authorLi, Xugang
dc.contributor.authorMa, Cuiping
dc.contributor.authorXie, Yingqiu
dc.date.accessioned2023-02-17T09:56:54Z
dc.date.available2023-02-17T09:56:54Z
dc.date.issued2022
dc.description.abstractHonghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both herbs act on signaling including kinases, response to inflammation and virus. Moreover, crocin likely has an antiviral effect due to its high affinity towards the human ACE2 receptor by simulation. The extract of Honghua and Xihonghua exhibited nanozyme/herbzyme activity of alkaline phosphatase, with distinct fluorescence. Thus, our data suggest the great potential of Honghua in the development of anti-COVID-19 agents.en_US
dc.identifier.citationMadikyzy, M., Tilegen, M., Nazarbek, G., Mu, C., Kutzhanova, A., Li, X., Ma, C., & Xie, Y. (2022). Honghua extract mediated potent inhibition of COVID-19 host cell pathways. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-15338-9en_US
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/6961
dc.language.isoenen_US
dc.publisherScientific Reportsen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectType of access: Open Accessen_US
dc.subjectCOVID-19en_US
dc.titleHONGHUA EXTRACT MEDIATED POTENT INHIBITION OF COVID‑19 HOST CELL PATHWAYSen_US
dc.typeArticleen_US
workflow.import.sourcescience

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
s41598-022-15338-9.pdf
Size:
3.88 MB
Format:
Adobe Portable Document Format
Description:
article
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
6.28 KB
Format:
Item-specific license agreed upon to submission
Description:

Collections