VALIDATION OF PIPELLE ENDOMETRIAL BIOPSY IN PATIENTS WITH ABNORMAL UTERINE BLEEDING IN KAZAKHSTANI HEALTHCARE SETTING

Simple item page
dc.contributor.authorAimagambetova, Gulzhanat
dc.contributor.authorKaiyrlykyzy, Aiym
dc.contributor.authorBapayeva, Gauri
dc.contributor.authorUkybassova, Talshyn
dc.contributor.authorKenbayeva, Kamila
dc.contributor.authorIbrayimov, Bakytkali
dc.contributor.authorLyasova, Alla
dc.contributor.authorBonaldo, Giulio
dc.contributor.authorBuzzaccarini, Giovanni
dc.contributor.authorNoventa, Marco
dc.contributor.authorAntonio Simone Laganà
dc.date.accessioned2021-08-12T09:03:06Z
dc.date.available2021-08-12T09:03:06Z
dc.date.issued2021-06-15
dc.description.abstractBackground: Abnormal uterine bleeding is a common sign which cover various conditions e/o pathologies. Different approaches are used to evaluate this condition. The aim of this study was to investigate the validity of Pipelle biopsy for endometrial sampling in Kazakhstani women with abnormal uterine bleeding. For this reason, we carried out a prospective study of 120 patients who underwent endometrial sampling due to abnormal uterine bleeding in a tertiary hospital setting in Kazakhstan. Methods: Statistics included descriptive analysis to evaluate the frequency of various endometrial conditions. The validity of Pipelle biopsy sampling was calculated by estimating sensitivity, specificity, accuracy, and positive and negative predictive values. For the Pipelle sampling validity assessment, we analyzed 120 samples, as 21 patients with insufficient samples were excluded. Results: Overall, concordance in histopathologic results was 92.93%. Pipelle sampling identified two cases of adenocarcinoma in our group. Moreover, endometrial hyperplasia was detected with 71.43% sensitivity, 98.82% specificity, PPV of 90.91% and NPV of 95.45%. However, the Pipelle reliability was low in cases of endometrial polyps. In conclusion, the Pipelle method was found to be valid for the diagnosis of endometrial hyperplasia and adenocarcinoma with high SN, SP, PPV and NPV. Conclusions: The Pipelle technique for evaluation of abnormal uterine bleeding in the Kazakhstani health care setting is a useful method with the highest efficacy in ruling out endometrial hyperplasia and diagnosing adenocarcinoma. If endometrial polyp was suspected under ultrasound scan in patients with abnormal uterine bleeding, physicians should consider other tools for endometrial sampling.en_US
dc.identifier.citationGulzhanat Aimagambetova, Aiym Kaiyrlykyzy, Gauri Bapayeva, Talshyn Ukybassova, Kamila Kenbayeva, Bakytkali Ibrayimov, Alla Lyasova, Giulio Bonaldo, Giovanni Buzzaccarini, Marco Noventa, Antonio Simone Laganà, Milan Terzic. Validation of Pipelle endometrial biopsy in patients with abnormal uterine bleeding in Kazakhstani healthcare setting. Clinical and Experimental Obstetrics & Gynecology, 2021, 48(3): 670-675.en_US
dc.identifier.issn0390-6663
dc.identifier.urihttps://ceog.imrpress.com/EN/10.31083/j.ceog.2021.03.2510#
dc.identifier.urihttps://doi.org/10.31083/j.ceog.2021.03.2510
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/5682
dc.language.isoenen_US
dc.publisherIMR Press Limiteden_US
dc.relation.ispartofseriesClinical and Experimental Obstetrics & Gynecology;2021 48 (3): 670-675
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectAbnormal uterine bleedingen_US
dc.subjectDilatation and curettageen_US
dc.subjectEndometrial hyperplasiaen_US
dc.subjectPipelleen_US
dc.subjectPostmenopausal bleedingen_US
dc.subjectType of access: Open Accessen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleVALIDATION OF PIPELLE ENDOMETRIAL BIOPSY IN PATIENTS WITH ABNORMAL UTERINE BLEEDING IN KAZAKHSTANI HEALTHCARE SETTINGen_US
dc.typeArticleen_US
workflow.import.sourcescience

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Article 64.pdf
Size:
119.2 KB
Format:
Adobe Portable Document Format
Description:
Article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
6.28 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Articles