The expanding Therapeutic Perspective of CCR5 Blockade

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dc.contributor.authorVangelista, Luca
dc.contributor.authorVento, Sandro
dc.date.accessioned2018-06-07T10:03:27Z
dc.date.available2018-06-07T10:03:27Z
dc.date.issued2018-01-12
dc.description.abstractCCR5 and its interaction with chemokine ligands have been crucial for understanding and tackling HIV-1 entry into target cells. However, over time, CCR5 has witnessed an impressive transition from being considered rather unimportant in physiology and pathology to becoming central in a growing number of pathophysiological conditions. It now turns out that the massive efforts devoted to combat HIV-1 entry by interfering with CCR5, and the subsequent production of chemokine ligand variants, small chemical compounds, and other molecular entities and strategies, may set the therapeutic standards for a wealth of different pathologies. Expressed on various cell types, CCR5 plays a vital role in the inflammatory response by directing cells to sites of inflammation. Aside HIV-1, CCR5 has been implicated in other infectious diseases and non-infectious diseases such as cancer, atherosclerosis, and inflammatory bowel disease. Individuals carrying the CCR5Δ32 mutation live a normal life and are warranted a natural barrier to HIV-1 infection. Therefore, CCR5 antagonism and gene-edited knockout of the receptor gained growing interest for the therapeutic role that CCR5 blockade may play in the attenuation of the severity or progression of numerous diseases.en_US
dc.identifier.citationVangelista, Luca, Vento, Sandro. (2018) The expanding Therapeutic Perspective of CCR5 Blockade. Frontiers in Immunology.en_US
dc.identifier.uridoi: 10.3389/fimmu.2017.01981
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/3333
dc.language.isoenen_US
dc.publisherFrontiers in Immunologyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectCCR5en_US
dc.subjectCCL5en_US
dc.subjectinflammationen_US
dc.subjectHIV-1en_US
dc.subjectcanceren_US
dc.titleThe expanding Therapeutic Perspective of CCR5 Blockadeen_US
dc.typeArticleen_US
workflow.import.sourcescience

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