Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System

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dc.contributor.authorHan, Bo
dc.contributor.authorTokay, Tursonjan
dc.contributor.authorZhang, Guangming
dc.contributor.authorSun, Peng
dc.contributor.authorHou, Shangwei
dc.date.accessioned2017-11-09T04:36:58Z
dc.date.available2017-11-09T04:36:58Z
dc.date.issued2017-03-06
dc.description.abstractEther-a-go-go ` 1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.ru_RU
dc.identifier.citationHan Bo et al.(>4), 2017(March 6), Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System, Oxidative Medicine and Cellular Longevity, Volume 2017, 13 pagesru_RU
dc.identifier.urihttps://doi.org/10.1155/2017/7371010
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/2763
dc.language.isoenru_RU
dc.publisherOxidative Medicine and Cellular Longevityru_RU
dc.rightsOpen Access - the content is available to the general publicru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectK+ channelru_RU
dc.subjectEAG1ru_RU
dc.subjectnervous systemru_RU
dc.subjectchannel regulationru_RU
dc.titleEag1 K+ Channel: Endogenous Regulation and Functions in Nervous Systemru_RU
dc.typeArticleru_RU

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