An Optimized Field Function Scheme for Nanoparticle Guidance in Magnetic Drug Targeting systems
Date
2015
Authors
Do, Ton Duc
Noh, Yeongil
Kim, Myeong Ok
Yoon, Jungwon
Journal Title
Journal ISSN
Volume Title
Publisher
IEEE
Abstract
Magnetic drug targeting is an approach to guide
and concentrate magnetic nanoparticles (MNPs) into the
diseased target organ after being injected into blood vessels.
Although many works for drug targeting have been conducted,
there are few studies on delivering the nanoparticles to the target
region. Drug delivery performance has not been addressed
sufficiently or fully. In this paper, we investigate the effect of
dominant factors to MNPs delivery performance. Then, an
optimized field function scheme with a pulsed magnetic
actuation is proposed to significantly improve the MNPs
guidance performance. With a specific condition of blood vessel
size, particle size, and applied magnetic field, the optimized
parameters of the field function are selected through extensive
simulation studies. We find out that the optimal negative and
positive time for the magnetic pulsed field mainly depends on
the exit time for particles to reach the bifurcation and the critical
time as the maximum time for them to reach the vessels wall,
respectively. With the chosen parameters, we show that ratios of
correctly guided particles in a Y-channel are reached to 100%.
In addition, to minimize the power consumption, a modified field
function (MFF) scheme is introduced. The MFF includes a
no-power time, called zero-time, between the positive and
negative time. It is shown that with the proposed MFF, the
energy consumption and the heating problem of the actuator
system can be significantly reduced. Therefore, the proposed
guidance scheme for MNPs can overcome the sticking issue and
maximize the guidance performance as well as reducing the
power consumption. It should be noted that the MFF can be
easily implement by programmable DC power supplies
connected to electromagnetic coils
Description
Keywords
Drug delivery, Field function, Magnetic drug targeting, Magnetic nanoparticle, Optimization
Citation
Ton Duc Do, Yeongil Noh, Myeong Ok Kim, Jungwon Yoon; 2015; An Optimized Field Function Scheme for Nanoparticle Guidance in Magnetic Drug Targeting systems; IEEE