The N-methyl-D-aspartate receptor (NMDAR) is critical for the induction of
synaptic plasticity and is essential for many forms of learning and memory. Activation of NMDAR
by glutamate requires the presence of D-Serine, which is an endogenous physiological coagonist
of the receptor and plays an important role in glutamate mediated NMDAR-dependent
synaptic plasticity in the brain. However, the role of D-serine in synaptic plasticity and learning
in chronic epilepsy is not known.