NU Research Week: abstracts
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Browsing NU Research Week: abstracts by Author "Adambekov, S."
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Item Open Access Polymer coating enhances affinity of bone marrow-derived MSCS to bone(Nazarbayev University, 2013) Yantsen, Y.; Askarova, Sholpan; Adambekov, S.; Murata, H.; Andersen, J.; D’Souza, S.; Edington, C.; Koepsel, R.; Russell, A.The polymer coated cells were shown to be stably attached to bone fragments for at least 2 hours, confirming the bone targeting potential of the polymer. Our next step will be to test this approach in rat model of osteoporosis to determine its actual performance in vivo.Item Open Access Role of ROS in AB42 mediated cell surface p-selectin expression and actin polymerization(Nazarbayev University, 2013) Tsoy, A.; Askarova, Sholpan; Shalakhmetova, T.; Umbayev, B.; Adambekov, S.; Zhumadilov, Z.The results of our study have indicated that Aβ42 induces expression of P-selectin on the surface of bEnd3 cells and promotes actin polymerization in a time dependent manner, and all these events correlate with ROS generation. The rapid, posttranslational cell signaling response mediated by ROS, may well represent an important physiological trigger of the micro vascular inflammatory response in AD and requires further investigations.Item Open Access Role of ROS in AB42 mediated cell surface P-selectin expression and actin polymerization(Nazarbayev University, 2014) Tsoy, A.; Askarova, Sholpan; Shalakhmetova, T.; Umbayev, B.; Adambekov, S.; Zhumadilov, Z.Blood-brain barrier dysfunction plays an important role in the onset and progression of Alzheimer's disease (AD). In the AD brains an increased deposition of A(3 in the cerebral vasculature has been found to correlate with increased transmigration of blood-born inflammatory cells and neurovascular inflammation [1]. Transmigration of leukocytes into brain parenchyma is a sequential process starting with primary capture to the endothelium and rolling adhesion mediated by tethering on selectins and selectin ligands. P-selectin is a type I transmembrane cell adhesion molecule which is stored in cytoplasmic Weibel-Palade bodies (WPb) and can be mobilized on the endothelial cell surface within minutes upon exposure to different pro-inflammatory agents; then it's rapidly cleared through endocytosis in 30 min. It has become evident that A(3 activates cerebral endothelial cells (CECs) and induces mobilization of P-selectin to the cell surface [2]. However, expression mechanisms of this receptor on the surface of brain endothelial cells under administration with A(342 remain unclear. Since P-selectin is stored in WPb, and there is an evidence of active role of ROS (reactive oxygen species) and actin filaments in the different stages of WPb exocytosis, in this study we examined the dynamic of P-selectin expression on the endothelial cell surface activated by A(342 in relation to ROS and actin polymerization.Item Open Access The Central Asian journal of global health to increase science productivity(Nazarbayev University, 2013) Freese, K.; Shubnikov, E.; LaPorte, R.; Adambekov, S.; Askarova, Sholpan; Zhumadilov, Z.; Linkov, F.The Central Asian Journal of Global Health (CAJGH) is the first peer reviewed, open access journal in Central Asia (CA) aimed at those working in the areas of public health, medicine, and bioengineering. Specifically, it focuses on a geographic region that is oftentimes not highlighted by existing journals. While the main focus at CAJGH is placed on CA countries, submissions from other regions are encouraged as well. Many accepted publications have come from outside the CA region.