(2016-05) Myngbay, A.; Bexeitov, Y.; Adilbayeva, A.; Yevstratenko, B. P.; Aitzhanova, R. M.; Otarbayev, N. K.; Adarichev, V.A.
Monitoring and suppressing activity of the pathological granulating pannus
tissue is essential for Rheumatoid Arthritis (RA) management. Synovial joints pain and tissue
destruction is a derivative of the pannus activity. In a mouse model for RAwe found CTHRC1,
a secreted and circulating protein, to be inducible in arthritis and correlated with the disease
severity. We performed a clinical investigation to ascertain the role of CTHRC1 in the progression
of the disease.